NOTCH1 and cancer: miR-34s are similarly methylated in several type of cancers, and their silencing affects cellular stemness by targeting CD44 molecule (CD44) and notch 1 (NOTCH1), cell cycle by targeting MYC proto-oncogene, bHLH transcription factor (MYC) and cyclin dependent kinase 6 (CDK6), and apoptosis by targeting BCL2 apoptosis regulator (BCL2) protein[84,85,86,87,88].