RBL2 and cancer: These subgroups of miRNAs, called “epi-miRNAs”, are often deregulated in human cancer and target specific epigenetic regulators, such as components of the polycomb repressive complexes 1 and 2 (PRC1 and PRC2), DNA methyl-transferases (DNMTs) and histone deacetylases (HDACs) enzymes, and the Retinoblastoma-Like protein 2 (RBL2) [31,32,33,34,35,36].