HLA-DRB1 and rheumatoid arthritis: Rheumatoid Arthritis (RA) pathogenesis is a multistep process between the dysregulated neuro-immune system, abnormal neuro-endocrine-immune and the individual’s genetic background (for example the HLA-DRB1 gene) that may predispose some people to excessive cytokine responses [1,2,3,4].