Although acute stimulation of the β-AR pathway has beneficial effects on heart function, a sustained activation of β-AR contributes to the development of pathological cardiac remodeling by inducing ventricular hypertrophy, fibrosis, and ultimately, arrhythmia and heart failure (HF), one of the most prevalent causes of mortality globally [3,4,5]. The gene discussed is ADRB2; the disease is cardiac hypertrophy.