ITGA6 and colorectal carcinoma: It is pertinent to note that one way by which ITGA6A promotes CRC cell proliferation is through the regulation of the Wnt/β-catenin pathway [22], for which MYC is a target gene, suggesting the existence of a feed forward loop that potentiates proliferation in CRC cells [37] while ITGA6B overexpression has previously been shown to negatively regulate MYC activity [12], supporting this interplay.