MYC and cancer: Considering that the proto-oncogene MYC controls the expression of a large array of genes [31] including those encoding various integrin subunits [13,32,33], is upregulated in up to 70% of CRC [34,35] and has been shown to be a modulator of various slicing regulators in cancer cells [36], we hypothesized that MYC could be involved in the up-regulation of ITGA6 expression and splicing in CRC.