The reduction of ITGB1 in response to the MYCi in the normal intestinal HIEC cells is consistent with the fact that ITGB1 contains the cognate CACGTG E-box in its promoter [37] while previous experiments have shown that MYC only plays a minor role on the ITGB1 promoter in colorectal cancer cells [32]. This evidence concerns the gene ITGB1 and colorectal cancer.