MYC and colorectal carcinoma: However, MYC overexpression had no net effect on ITGA6 promoter activation in CRC T84, Caco-2/15 and SW620 cells (Figure 4d) although ITGA6-luciferase activity can be inhibited by treatment with the MYCi as shown with SW620 cells (DMSO: 1.66 ± 0.21; MYCi: 0.99 ± 0.16, p < 0.01).