Indeed, on one hand, the alternative splicing of ITGA6 has been well documented over the last few years, being potentially regulated by epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) [23,24,25,26], RNA Binding Motif Protein 47 (RBM47) [24], the RNA-binding protein Muscleblind (MBNL1) and the RNA-binding protein FOX2 homologue (RBFOX2) [27] as well as the polypyrimidine tract-binding protein 1 (Ptbp1) [28], but the potential influence of these factors on ITGA6 splicing has not been studied in the context of colorectal cancer cells. The gene discussed is PTBP1; the disease is colorectal cancer.