We recently documented the suitability of mice deficient in IFN-α/β and -γ receptors as an animal model for ZIKV, as they are highly susceptible to ZIKV infection and disease, developing rapid viremic dissemination in visceral organs and brain and dying 7–8 days post-infection [43], and evaluated doses as low as 1 PFU. The gene discussed is IFNA1; the disease is Zika virus infectious disease.