PPARGC1A and type 2 diabetes mellitus: Acute exercise resulted in increased levels of miR-1, miR-107, miR-18168 and miR-133a69 and diminished miR-23 levels which it can up-regulated peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α).70 Furthermore, through analysis of epigenetic changes in skeletal muscle of T2D patients in response to both types of exercise revealed a metabolic reprogramming.1