Decreased miR-26b expression is involved in obesity-related insulin resistance in adipocytes.74 In insulin resistant 3T3-L1 adipocytes, miR-320 and miR-29 mediate insulin response through the PI3K/AKT pathway.75 Some other microRNAs such as miR-21,76 miR-93,77 miR-103, miR-107,78 miR-14379 and miR-22180 are concerned in insulin sensitivity of adipocytes (Table 3). This evidence concerns the gene AKT1 and obesity due to melanocortin 4 receptor deficiency.