Multiple lines of evidence underscore the importance of miRNAs in adipogenesis and obesity.72 Over-expressed miR-223 in adipose tissues of IR patients reduced GLUT4 protein content and subsequently impaired glucose uptake in these tissues.73 MiR-26b increases insulin sensitivity via the PTEN/PI3K/AKT pathway. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.