But it should be noted that, BDL model is characterized by higher damages to cholangiocytes and bile duct hyperplasia at peri-portal region, while recent studies which indicated the protective role of α7nAChR activation focused on ischemia/reperfusion injury and Fas-induced hepatitis in the liver which mainly involve hepatocytes.17-19 Therefore, this hepatocytes injury models may be more appropriate for investigating of vagus-α7nAChR axis in the liver. Here, CHRNA7 is linked to Hepatitis.