Reports in patients with sepsis have indeed documented elevated levels of ultra-large multimers of vWF together with deficiency of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS-13), which is responsible for degradation of these multimers53,54, but the direct effect of histones on ADAMTS-13 is not currently known. Here, ADAMTS13 is linked to Sepsis.