PLOD1 and androgen insensitivity syndrome: Kulis et al. [272] found that levels of FSH (follicle-stimulating hormone), LH (luteinizing hormone) and oestradiol were lower in premenarcheal AIS patients than in normal premenarcheal girls, while higher levels of progesterone, oestrone, oestriol, RANKL (receptor activator of nuclear factor kappa-B ligand), osteocalcin and AP (alkaline phosphatase) were observed in the group of AIS patients.