Interestingly, some phenotypes of the MYO6 KO mouse, such as hypertrophic cardiomyopathy and gliosis in the brain (Mohiddin et al., 2004, Osterweil et al., 2005), are reminiscent of mitochondrial diseases (Chinnery, 2015) and neurodegenerative disorders, respectively. Here, MYO6 is linked to hypertrophic cardiomyopathy.