IL1B and non-small cell lung carcinoma: In our study, undetectable IL-1b is associated with poor prognosis which agrees with these preclinical observations, but not with a clinical study that reported that high IL-1b was independently associated with worse OS (HR, 2.24; 95% CI, 1.01-4.98; P = .047) in stage IIIB-IV NSCLC patients treated with chemotherapy.26