These findings are consistent with previous reports demonstrating podocyte Notch activation in chemically induced models of glomerulosclerosis and in human biopsies of glomerular disease.28, 36, 37, 38 Increased podocyte Hes1, Hes3, Hes5 and Hey1, Hey2, and HeyL have been found in streptozotocin- and puromycin aminonucleoside–induced glomerulosclerosis.28 Here, HES1 is linked to glomerulosclerosis.