At postnatal day 16 (P16) when myelination is normally underway, PDGFRa-Cre; Acvr1bfl/fl mice displayed a tremor, hunched posture, and a stiff tail (Online Resource Supplemental Video 1), all behaviors associated with myelin abnormalities [17, 44] or damage (e.g. in experimental autoimmune encephalomyelitis) [12, 58]. Here, PDGFRA is linked to experimental autoimmune encephalomyelitis.