Expression of the LS mutant Q510E causing severe hypertrophic cardiomyopathy in infants inhibits the differentiation of P19CL6 cells in cardiomyocytes mostly due to increased Akt/GSK3β/β-catenin activity [3, 18, 44–46, 65], and induces hypertrophic cardiomyopathy in mice through mTOR pathway [3]. This evidence concerns the gene AKT1 and hypertrophic cardiomyopathy.