COL4A4 and Friedreich ataxia: In addition to the probable founder effect suggested here, similar phenomena have been projected for a number of other mutations or diseases among the population of Cyprus such as the predominance of the IVS1-2A > G mutation in the 5α Steroid Reductase type 2 (SRD5A2) gene in patients with 5 Alpha Reductase deficiency [35], the frequency of 1:7–1:10 for Friedreich ataxia [36] and the reported novel COL4A4 gene mutation p.Gly871Cys in a cohort of Greek-Cypriot families with thin membrane nephropathy and focal segmental glomerulosclerosis [37].