Additionally, in an ovine model of PCOS which exhibits increased GnRH/LH pulse frequency and an abolished GnRH/LH surge, NKB and dynorphin expression is reduced in the middle and caudal ARC, further supporting that KNDy neurons in this region are important regulators of GnRH release57. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.