Activation of LXRα triggers fatty liver disease and up-regulates genes associated with lipid metabolism, such as those encoding sterol regulatory element-binding protein-1c (SREBP1c), ATP-binding cassette transporter A1 (ABCA1) and fatty acid synthase (FAS), which are believed to cause hepatic lipogenesis19–21,36,37. The gene discussed is NR1H3; the disease is fatty liver disease.