TARDBP and neuroblastoma: After normalization with luciferase readings from chelerythrine-treated cells expressing the constitutively active NanoLuc luciferase (Fig. 3F), effects on TDP-43 were less pronounced at 4 μM (71% of non-treated cells), 10 μM (24%), 25 μM (18%) and 62.5 μM chelerythrine (28%) owing to a possible toxic effect to the N2a neuroblastoma cells at the highest concentration during the 60 min incubation.