Paradoxically, in pancreatic cancer cells, it is reported that inhibition of RAP80 using siRNAs, the cell apoptosis is significantly induced, indicated by the expression of apoptotic biomarkers, including BAX, BCL-2, SURVIVIN, and Caspas-8 at both mRNA and protein levels23, revealing an oncogenic role of RAP80 in pancreatic tumorigenesis. Here, UIMC1 is linked to familial pancreatic carcinoma.