It was also reported that the conversion of prostate tumor to high-grade carcinoma and metastasis requires further changes, namely loss of PTEN (NM_000314), EPHB2 (NM_017449) and microRNA-101, c-MYC amplification (NM_002467) as well as overexpression of Hepsin (NP_002142), PIM1 (NP_001230115) and EZH2 (NP_004447)13. Here, HPN is linked to prostate neoplasm.