In one of the pair of samples, non-smoking sample 1Ae is from more advanced stage (metastatic adenocarcinoma with a higher tumor grade 3) whereas the smoking tumor tissue sample 1Af is from a comparatively less aggressive breast cancer (non-metastatic and tumor grade 2), but EZH2 expression is still significantly high in cancer tissue from smoking individual. The gene discussed is EZH2; the disease is neoplasm.