Intriguingly, we observed that the transcription factor Yin Yang 1 (YY1) directly activated the promoter of miR-135b and formed a ‘miR-135b–BMAL1–YY1’ loop, whose expression was related to the clinicopathological factors, survival outcomes and chemoresponsiveness in patients with PC. The gene discussed is BMAL1; the disease is pachyonychia congenita.