Consistent with our observations in TCGA human tumor samples suggesting a particularly close relationship between ZAK and ZEB1, we also found that several other well-characterized EMT transcription factors, such as Snail 1, Snail 2, and Twist 1, are largely unchanged upon silencing ZAK in these mesenchymal cancer cells (Fig. 3a). Here, MAP3K20 is linked to neoplasm.