The rs9642880 G > T polymorphism is a common variant that lies upstream of c-MYC on chromosome 8q2418,19.Various enhancers that can regulate the transcription of c-MYC are found in this region, and the rs9642880 G > T polymorphism has been reported to affect the expression of c-MYC in bladder cancer. The gene discussed is MYC; the disease is urinary bladder carcinoma.