GHRL and Cachexia: As such, a functional ghrelin system ensures protection from life-threatening falls in blood glucose in adult mice subjected to severe caloric restriction and in juvenile mice subjected to acute fasting [15], [16], [19], [20], [21], [22], minimizes depressive-like behaviors in mice subjected to chronic psychosocial stress, mediates the antidepressant-like and anxiolytic-like behavioral effects of caloric restriction [23], [24], and restricts body weight loss and stalls mortality associated with chronic anorexia/cachexia conditions [25].