Striking differences were reported in the predicted peptide repertoire of four HLA-B alleles that correlated with the speed of progression from HIV infection to AIDS, with the fastidious HLA-B*57:01 and HLA-B*27:05 alleles associated with long-term non-progression compared with the promiscuous HLA-B*07:02 and HLA-B*35:01 associated with rapid progression [59]. This evidence concerns the gene HLA-B and AIDS.