Our data are similar to those in literature; Cumpanas et al. analyzed 183 patients with BPH (PV < 40 mL) treated with tamsulosin and found that approximately 40% of the patients in the high IPP group were treatment nonresponders and had significantly worse outcomes than patients in the low IPP group at 3 months [20]; even in a more recent paper Kalkanli et al. [26] showed that an increase in IPP was associated with a lower response level to medical treatment and indicated a significant negative correlation between IPP-Qmax and IPP-post treatmens IPSS. The gene discussed is IPP; the disease is benign prostatic hyperplasia.