To better explore the relationship between non-lyDCIS, lyDCIS and miCa, we performed a cluster analysis which evaluated distribution of those 3 categories according to several pathobiological characteristics not related to TILs, reported in the literature to have prognostic significance in invasive or in situ BC: lesion size, nuclear grade, mitotic and Ki67 index, molecular subtype, presence of necrosis or microcalcifications. Here, MKI67 is linked to breast cancer.