In terms of TIL composition, miCa contained significantly more CD8+, CD4+ and CD38+ cells (p = 0.016, p = 0.001 and p = 0.024, respectively) whereas no statistically significant difference between DCIS and miCa was observed in the number of FoxP3+ or CD20+ cells. This evidence concerns the gene CD4 and ductal breast carcinoma in situ.