Pharmacological inhibition of ROCK with fasudil or Y27632 suppresses acute pressor responses of Ang II but does not reduce blood pressure chronically, supporting the role of RhoA/ROCK in acute vasoconstriction, rather than in mechanisms associated with adaptive vascular remodelling in hypertension that occur chronically with Ang II infusion.90–93. The gene discussed is AGT; the disease is Hypertension.