LGALS4 and infection: To confirm that the survival phenotype observed in CrebA RNAi flies upon infection was solely due to loss of CrebA expression, we co-expressed a CrebA RNAi construct and a CrebA overexpression construct in flies (Gal80ts; c564-Gal4 > UAS-CrebA, UAS-CrebA-IR) and infected them with P. rettgeri. We observed no significant difference between the survival of infected control flies and that of infected flies co-expressing both the RNAi and overexpression constructs, indicating that changes in CrebA expression are uniquely responsible for the lowered survival phenotype observed (Fig 6A).