Interestingly, overexpressionof miR-200a, miR-200b, miR-15a, resulted in the down-regulation of BMI1 and UbH2A in the CD44+ Cancer Stem Cell population of MDAMB-231 cells(Fig 6A, 6B and 6C) demonstrating a definite role in maintaining gene silencing and maintainingcancer stemness. Here, BMI1 is linked to cancer.