Although we currently have no evidence that Celastrol affects the activity of super enhancers in AML cells it is nevertheless conceivable that the inhibition of the Myb-C/EBPβ-p300 transcriptional module by Celastrol might diminish the activity of such enhancers, similar to its effect on the mim-1 enhancer. This evidence concerns the gene EP300 and acute myeloid leukemia.