From the SSH libraries, a total of 17 genes were identified and verified using qPCR and Western blotting, and the results suggested that six genes (Sardh, Slc39a7, Arg1, Pfn1, Cth, Fabp4) may be associated with metabolism and diabetes in gerbils, with a further two genes having support from qPCR but not Western blotting analysis (Sod1, P4hb). This evidence concerns the gene SARDH and diabetes mellitus.