Multivariable adjusted predictors associated with HFhospitalizations were age (HR 1.51 [95%CI 1.002; 2.29], p = 0.049), BMI (1.46 [1.14;1.87], p = 0.003), diabetes mellitus (2.72 [1.57; 4.71], p = 0.0004), history ofvalve surgery (3.10 [1.58; 6.10], p = 0.001), QTc interval on the ECG (1.44 [1.14;1.83], p = 0.002), BNP (1.92 [1.30; 2.83], p = 0.001) and history of arrhythmiaintervention (0.41 [0.23; 0.76], p = 0.004), as shown in Table 2. This evidence concerns the gene NPPB and diabetes mellitus.