Independent predictors for HF were body mass index (HR1.40 [95%CI 1.17; 1.66], p = 0.0002), chronic kidney disease (2.27 [1.49;3.45], p = 0.0001), diabetes mellitus (2.13 [1.41; 3.24], p = 0.0004), QTcinterval (1.25 [1.04; 1.49], p = 0.02), brain natriuretic peptide (2.19[1.73; 2.77], p<0.0001), diastolic blood pressure (0.79 [0.65; 0.96], p =0.02), history of pulmonary vein isolation or electrical cardioversion (0.54[0.36; 0.80], p = 0.003) and serum chloride (0.82 [0.70; 0.96], p =0.02). This evidence concerns the gene NPPB and chronic kidney disease.