The suppression of tumor growth was associated with marked decrease in tumor microvascular density count (CD31+ or CD34+) of xenografts by immunohistochemistry as well as decrease in focal adhesion kinase and AKT activities suggesting suppression of angiogenesis, tumor cell migration and growth in TIMP-2 and Ala+TIMP-2 mice xenografts [248]. This evidence concerns the gene AKT1 and neoplasm.