Activation of MMP-1-PAR1 induces the secretion of interleukin-8 and growth related oncogene α from ovarian cancer cells, which act on endothelial chemokine CXCR1/2 receptors leading to endothelial cell proliferation, tube formation and cancer cell invasion [212,213]. This evidence concerns the gene CXCL8 and ovarian carcinoma.