High mRNA expression of MMP-2, MMP-9, MT1-MMP and TIMP-2 in primary ovarian tumors and stromal compartments was associated with poor survival in ovarian cancer patients, suggesting that MMP-2, MMP-9, MT1-MMP and TIMP-2 are valid markers of poor survival in advanced-stage ovarian carcinoma [190]. Here, TIMP2 is linked to ovarian neoplasm.