In addition, ADAM-17 has been shown to cleave the interleukin-6 receptor (IL-6R) resulting in the shedding of soluble interleukin-6 (sIL-6) which is a prerequisite for the pathogenesis of interleukin 6 (IL-6) trans-signaling effecting multiple cellular functions related to cancer and inflammation [96]. Here, IL6R is linked to cancer.