For example, it has been shown that the selective inhibition of ADAM12 catalytic activity can result through the removal of the AB-loop in N-TIMP-2, which impairs the interaction of ADAM12 with ADAM17/TACE2, resulting in the loss of ADAM12 targeted cell surface shedding of growth factor receptors and gelatinases required for the tumorigenic phenotype of cancer cells [239]. This evidence concerns the gene TIMP2 and cancer.