High mRNA expression of MMP-2, MMP-9, MT1-MMP and TIMP-2 in primary ovarian tumors and stromal compartments was associated with poor survival in ovarian cancer patients, suggesting that MMP-2, MMP-9, MT1-MMP and TIMP-2 are valid markers of poor survival in advanced-stage ovarian carcinoma [190]. This evidence concerns the gene TIMP2 and ovarian carcinoma.