A screening study using an orthotopic ovarian carcinoma model in nude mice recently demonstrated that the mRNA levels of TIMP-2, MMP-2 and other ovarian cancer associated proteins such as cytokeratin -7 (CK-7), cancer antigen-125 (CA-125), tumor suppressor P53 and survivin, were significantly higher in cancer tissue than the middle paraneoplastic tissue and remote paraneoplastic tissue and normal ovarian tissue [193]. This evidence concerns the gene MUC16 and ovarian carcinoma.