TGFB1 and scleroderma: The dependence of pro-TGFβ on αVβ6 for activation, and the fact that TGFβ is a well-known master regulator of fibrosis [224], has led to the suggestion that the inhibition of αVβ6 integrin binding may represent a clinical strategy to treat diseases characterized by fibrosis, such as scleroderma [225].