TGFB1 and Hepatic fibrosis: It was noteworthy that OA’s derivatives, such as CPU-II2, CDDO-EA, and Oxy-Di-OA, could attenuate the expression of TNF-α, α-SMA and TGF-β, and improve histologic and serologic markers of fibrosis in CCl4-induced hepatic fibrosis in rats [19,37,38].