EPO and chronic kidney disease: Induction of EpoR expression in non-hematopoietic tissues following injury has been correlated with the tissue protective effect of Epo administration in a variety of disease models, including stroke [122,123], traumatic brain injury [23,124], hypoxic ischemic encephalopathy (HIE) in neonates [125,126,127], peripheral nerve injury [128,129], ischemic reperfusion injury of the heart [106,130] and kidney [54,55] and chronic kidney disease [56].