Studies on ovarian carcinoma cells, that endogenously express both EphB4 and EpoR, demonstrated that both ephrin-B2 and Epo directly activate EphB4, causing increased proliferation and invasive migration mediated by Scr kinase (a cytosolic non-receptor tyrosine kinase) and STAT3 [185]. Here, EPHB4 is linked to ovarian carcinoma.