Concluding: i) glycobiology of galectin-3; ii) the biological effects induced by galectin-3 in tumor cells in vitro; iii) the extensive characterization of galectin-3 expression performed on human thyroid tissues ex vivo; iv) the possibility to imaging thyroid cancer in vivo by using a galectin-3 immuno-PET represent all together a fashionable journey from the bench to the bed-side, which has already provided important improvements in clinical practice. The gene discussed is LGALS3; the disease is thyroid cancer.