TNF and cancer: Some effects correlated with the presence of OS and HC are increased production of tumor necrosis factor alpha, which activates OS reactions and induces hepatic fibrosis and eventually, cancer [7]; release of apoptotic factors (oncoproteins and tumor suppressor factors) by damaged mitochondria [8]; shortening of telomeres and damage in the DNA of liver cells, leading to cancer cell mutations [6]; and stimulation of the activity of nuclear factor kappa B, which also induces OS in liver cells [9].