Specifically, conditional infection of the Gs/Gq double signaling-deficient mutant ADGRG2-HM696AA or the Gq signaling-deficient mutants Y708A and RK803EE did not result in differing levels of accumulation in the efferent ductules compared with those in Adgrg2-/Y mice infected with a control virus. The gene discussed is ADGRG2; the disease is infection.