In a study by Nicolini et al. (11), patients were divided into two groups; the first group of patients who received medical therapy in case of negative conventional imaging findings but significant increase in one or more components of CEA-TPA-CA 15-3 tumor marker panel (“tumor marker guided” treatment) and the second group of patients who were treated only after radiologically confirmed recurrence (conventional treatment). This evidence concerns the gene PLAT and neoplasm.