TGFB2 and Marfan syndrome: Tgfb2+/− mice showed dilatations of the aortic annulus and aortic root, a pattern similar to that of LDS and MFS patients (Loeys et al., 2005; Mc Kusick, 1955), confirming that loss‐of‐function of one Tgfb2 allele is sufficient to cause aortic root aneurysm.