Further, systemic administration of the TRPV1 antagonist SB-366791 markedly reduced pain behavior in rats with CP (but not in control animals, suggesting a specific role in the sensitized but not the healthy state).85 The TRPV1 molecule may also be theoretically involved in increased pain sensation in patients who experience pancreatitis “flares,” perhaps via a mechanism involving trypsin that may be released during such episodes (Fig. 2). Here, TRPV1 is linked to pancreatitis.