TNF and rheumatoid arthritis: Although the function of this protein is not clear, the PSORS1C1 gene polymorphism has been reported to be associated with the susceptibility to psoriasis, hyper proliferative skin disorder [30, 31], and rheumatoid arthritis [32] whereas the BAT1 gene encodes a protein that downregulated inflammatory cytokine production in splicing and RNA export mechanism such as tumor necrosis factor (TNF), interleukin-1, and interleukin-6 [33].