miR-203 is an independent prognostic factor of OS for RCC patients (HR 3.071, 95% CI 1.719–6.374, P = 0.001), as low miR-203 expression predicts a shorter OS (P < 0.05). In vitro experiments showed that miR-203 inhibited RCC cell growth and migration, through directly targeting FGF2, as evidenced by partial attenuation of the tumor suppressive effect in a FGF2 overexpression model. This evidence concerns the gene FGF2 and renal cell carcinoma.