CD276 and nonpapillary renal cell carcinoma: All patients with high levels of miR-187 (T/N > 1) survived 5 years after surgery; in contrast only 42% of those with low-level of miR-187 had survived at this time point (T/N < 0.42), suggesting a suppressive role of miR-187 in ccRCC progression. In vitro experiments showed that overexpression of miR-187 inhibited tumor cell growth and decreased motility via directly targeting B7 homolog 3 (B7-H3).