Meanwhile Xiong Hao examined miR-34a/Sirtuin 1 (SIRT1)/p53 signaling in cochlear hair cells during aging, and the result of their work support a link between age-related cochlear hair cell apoptosis and miR-34a/SIRT1/p53 signaling, so they also believed this signaling may present an attractive target for the development of new drugs for AHL treatment [47]. This evidence concerns the gene TP53 and acute hemorrhagic leukoencephalitis.