To provide evidence that SMARCA2 is required for the antiviral activity of MxA not only in the context of a reporter virus but also with wild type virus infection, we performed siRNA knockdown as before and infected A549-MxA cells and A549-shMxA cells with the MxA-sensitive H5N1 strain A/Thailand/1(KAN-1)/2004 at an MOI of 0.0019,18. This evidence concerns the gene MX1 and viral infectious disease.