15 host cell factors qualified as high-confidence hits based on enrichment with the MxA bait vs. the GFP bait during H5N1-RL infection (Log2FC > 2; p-value < 0.05 under statistical conditions to minimize false negatives or Log2FC > 2; p-value < 0.1 under statistical conditions to minimize false positives) (Supplementary Table S3). Here, MX1 is linked to infection.