SMARCA2 and neoplasm: In addition, genes downregulated in SMARCA2-high tumors were strongly enriched in ribosome RNA processing, translation, cell cycle, DNA-replication, and mitosis-related functions and pathways (Fig. 5j; Supplementary Figs S3d and S4b), and often presented E2F (P = 1.05×10−26), MYC (P = 3.9×10−16) and ELK1 (P = 1.2 × 10−11) binding sites, suggesting a reduced proliferation of these tumor cells.