Analyzing liver hepatocellular carcinoma and kidney renal clear cell carcinoma TCGA cohorts, we found that high levels of SMARCA4 and SMARCA2 transcripts were inversely associated with survival prognosis, clinicopathological factors, and gene expression patterns, pointing to an inverse role of SMARCA4 and SMARCA2 in cancer. The gene discussed is SMARCA2; the disease is cancer.