AKR1C1 and chronic myelogenous leukemia, BCR-ABL1 positive: Since many curcumin-binding candidates identified in this study (CBR1/3, GSTP1/O1, NQO1/2, AKR1C1/D1, PRDX1, GLO1, and ADH1A shown in Table 1) belong to the enzymes involved in the metabolism of ROS and oxidative-stress products (such as Reactive Carbonyl Species, RCS)18, and because curcumin inhibits the enzymatic activity of CBR119, GSTP120, NQO121, and GLO122in vitro, we speculated that the treatment with curcumin up-regulates intracellular ROS levels in CML-derived leukemic cells.