AKR1C1 and acute myeloid leukemia: We analyzed the expression levels of curcumin interactors (CBR1, CBR3, GST-P, GST-O, NQO1, NQO2, PRDX1, ADH1A, AKR1C1, AKR1D1, and GLO1) in a Gene Expression Omnibus (GEO) dataset of 22 healthy donors, 18 cases of CML, 461 cases of AML, and 100 cases of T-ALL, and found that they were all significantly overexpressed in CML, AML and ALL (mostly P < 0.001, except for PRDX1 in CML (P < 0.005)) (Fig. 7).